Roger G Pertwee Selected Research

3- (2- nitro- 1- phenylethyl)- 2- phenyl- 1H- indole

1/2020	Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.
11/2018	Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.

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Roger G Pertwee Research Topics

Disease

7	Nausea 01/2021 - 02/2009
7	Pain (Aches) 01/2021 - 08/2002
7	Multiple Sclerosis 08/2017 - 08/2002
4	Neoplasms (Cancer) 05/2022 - 02/2009
4	Inflammation (Inflammations) 01/2022 - 04/2007
4	Vomiting 01/2021 - 02/2009
3	Hyperalgesia 12/2019 - 06/2010
2	Neuroblastoma 05/2022 - 02/2009
2	Memory Disorders (Memory Loss) 02/2022 - 12/2004
2	Edema (Dropsy) 01/2022 - 05/2012
2	Glaucoma 11/2021 - 01/2021
2	Cancer Pain 01/2013 - 12/2012
2	Neuralgia (Stump Neuralgia) 12/2012 - 02/2009
2	Disease Progression 05/2012 - 09/2011
2	Huntington Disease (Huntington's Disease) 05/2012 - 09/2011
2	Autoimmune Diseases (Autoimmune Disease) 09/2007 - 04/2007
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2007 - 08/2002
1	Tics (Tic) 08/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2022
1	Epilepsy (Aura) 01/2021
1	Autistic Disorder (Autism) 01/2021
1	Breast Neoplasms (Breast Cancer) 01/2020
1	Obesity 01/2020
1	Substance-Related Disorders (Drug Abuse) 01/2020
1	Tobacco Use Disorder (Nicotine Dependence) 12/2019
1	Anxiety Disorders (Anxiety Disorder) 01/2018
1	Ocular Hypertension (Glaucoma, Suspect) 10/2017
1	Parkinson Disease (Parkinson's Disease) 11/2015
1	Otitis 07/2015
1	Colonic Neoplasms (Colon Cancer) 04/2014
1	Aberrant Crypt Foci 04/2014
1	Polyps 04/2014
1	Carcinogenesis 04/2014
1	Colorectal Neoplasms (Colorectal Cancer) 04/2014
1	Gliosis 05/2012
1	Reperfusion Injury 04/2012
1	Hypothermia 01/2011
1	Prostatic Neoplasms (Prostate Cancer) 09/2010

Drug/Important Bio-Agent (IBA)

15	CannabinoidsIBA 05/2022 - 08/2002
7	Cannabinoid Receptors (Cannabinoid Receptor)IBA 02/2022 - 08/2002
7	CannabidiolIBA 01/2021 - 12/2008
5	EndocannabinoidsIBA 01/2020 - 08/2002
4	CB2 Cannabinoid ReceptorIBA 08/2022 - 01/2012
4	Pharmaceutical PreparationsIBA 01/2020 - 06/2011
4	Dronabinol (THC)FDA LinkGeneric 12/2012 - 08/2002
4	nabiximols (Sativex)IBA 12/2012 - 02/2009
3	EstersIBA 01/2021 - 01/2018
3	cannabidiolic acidIBA 01/2021 - 01/2018
3	Neuroprotective AgentsIBA 05/2012 - 12/2008
2	HU 308IBA 08/2022 - 07/2015
2	Dehydroepiandrosterone (DHEA)IBA 01/2020 - 09/2010
2	Analgesics (Analgesic Drugs)IBA 01/2020 - 02/2009
2	3- (2- nitro- 1- phenylethyl)- 2- phenyl- 1H- indoleIBA 01/2020 - 11/2018
2	5-HT1A Serotonin ReceptorIBA 01/2018 - 06/2011
2	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)IBA 01/2018 - 06/2011
2	Formaldehyde (Formol)FDA Link 09/2014 - 06/2010
2	nabilone (Cesamet)FDA Link 12/2012 - 08/2002
2	Cannabinoid Receptor AgonistsIBA 01/2011 - 08/2007
1	4-iodo-2,5-dimethoxyphenylisopropylamine (DOI-P)IBA 08/2022
1	Biological ProductsIBA 05/2022
1	2-phenylindoleIBA 11/2021
1	GTP-Binding Proteins (G-Protein)IBA 01/2021
1	Therapeutic UsesIBA 01/2020
1	Nicotine FDA Link 12/2019
1	Freund's AdjuvantIBA 11/2018
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2018
1	HU-580IBA 01/2018
1	Serotonin 5-HT1 Receptor AntagonistsIBA 01/2018
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2018
1	tetralinIBA 01/2018
1	Hypnotics and Sedatives (Sedatives)IBA 08/2017
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2015
1	AnkyrinsIBA 09/2014
1	TRPA1 Cation ChannelIBA 09/2014
1	AzoxymethaneIBA 04/2014
1	Insulin-Like Growth Factor I (IGF-1)IBA 05/2012
1	Nerve Growth Factors (Neurotrophins)IBA 05/2012
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 05/2012
1	malonic acid (malonate)IBA 05/2012
1	LigandsIBA 01/2012
1	SaccharinIBA 06/2011
1	cannabigerolIBA 06/2011
1	Calcium Gluconate (CBG)IBA 06/2011
1	AntiemeticsIBA 06/2011
1	(6aR,10aR)- 3- (1- methansulfonylamino- 4- hexyn- 6- yl)6a,7,10,10a- tetrahydro- 6,6,9- trimethyl- 6H- dibenzo(b,d)pyranIBA 01/2011
1	SulfonamidesIBA 01/2011
1	Eicosapentaenoic AcidIBA 09/2010
1	Docosahexaenoic AcidsIBA 09/2010
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 09/2010
1	Androgen Receptors (Androgen Receptor)IBA 09/2010
1	Guanosine 5'-O-(3-Thiotriphosphate)IBA 06/2010
1	ColforsinIBA 06/2010
1	CarrageenanIBA 06/2010
1	Hexachlorobenzene (HCB)IBA 06/2010
1	Cyclic AMP (AMP, Cyclic)IBA 06/2010
1	AM 251 (AM251)IBA 04/2009

Therapy/Procedure

2	Ovariectomy (Oophorectomy) 01/2022 - 07/2015
2	Drug Therapy (Chemotherapy) 12/2012 - 02/2009
1	Self Administration (Administration, Self) 12/2019
1	Therapeutics 01/2013